Structural organization of the prefrontal white matter pathways in the adult and aging brain measured by diffusion tensor imaging. (2024)

Malykhin, N., Vahidy, S., Michielse, S., Coupland, N., Camicioli, R., Seres, P., & Carter, R. (2011). Structural organization of the prefrontal white matter pathways in the adult and aging brain measured by diffusion tensor imaging. , 216(4), 417-431. https://doi.org/10.1007/s00429-011-0321-1

Malykhin, N ; Vahidy, S ; Michielse, S et al. / Structural organization of the prefrontal white matter pathways in the adult and aging brain measured by diffusion tensor imaging. In: . 2011 ; Vol. 216, No. 4. pp. 417-431.

@article{2bc39cce487b40e7997fb0af239375f7,

title = "Structural organization of the prefrontal white matter pathways in the adult and aging brain measured by diffusion tensor imaging.",

abstract = "AbstractPrevious diffusion tensor imaging (DTI) studies confirmed the vulnerability of frontal callosal fibers to normal aging. The present study extended this examination systematically to other prefrontal white matter regions. Structural magnetic resonance imaging and DTI datasets were acquired from 69 healthy subjects aged 22–84 years. The prefrontal white matter was parcellated into several anatomical sub-regions: medial and lateral orbitofrontal white matter, dorsolateral prefrontal white matter, and medial prefrontal white matter, using reliable DTI-tractography protocols. Tract-specific characteristics were calculated using Matlab. Regression models were used to determine the relationship between age and structural integrity of white matter tracts. The results of our study demonstrate regional age-related changes in the prefrontal white matter tracts of the human brain. This study was cross-sectional and therefore additional longitudinal studies are needed to confirm our findings.",

author = "N Malykhin and S Vahidy and S Michielse and N Coupland and R Camicioli and P Seres and R Carter",

year = "2011",

month = nov,

doi = "10.1007/s00429-011-0321-1",

language = "English",

volume = "216",

pages = "417--431",

journal = "Brain Structure & Function",

issn = "1863-2653",

publisher = "Springer Verlag",

number = "4",

}

Malykhin, N, Vahidy, S, Michielse, S, Coupland, N, Camicioli, R, Seres, P & Carter, R 2011, 'Structural organization of the prefrontal white matter pathways in the adult and aging brain measured by diffusion tensor imaging.', , vol. 216, no. 4, pp. 417-431. https://doi.org/10.1007/s00429-011-0321-1

Structural organization of the prefrontal white matter pathways in the adult and aging brain measured by diffusion tensor imaging. / Malykhin, N; Vahidy, S; Michielse, S et al.
In: , Vol. 216, No. 4, 11.2011, p. 417-431.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Structural organization of the prefrontal white matter pathways in the adult and aging brain measured by diffusion tensor imaging.

AU - Malykhin, N

AU - Vahidy, S

AU - Michielse, S

AU - Coupland, N

AU - Camicioli, R

AU - Seres, P

AU - Carter, R

PY - 2011/11

Y1 - 2011/11

N2 - AbstractPrevious diffusion tensor imaging (DTI) studies confirmed the vulnerability of frontal callosal fibers to normal aging. The present study extended this examination systematically to other prefrontal white matter regions. Structural magnetic resonance imaging and DTI datasets were acquired from 69 healthy subjects aged 22–84 years. The prefrontal white matter was parcellated into several anatomical sub-regions: medial and lateral orbitofrontal white matter, dorsolateral prefrontal white matter, and medial prefrontal white matter, using reliable DTI-tractography protocols. Tract-specific characteristics were calculated using Matlab. Regression models were used to determine the relationship between age and structural integrity of white matter tracts. The results of our study demonstrate regional age-related changes in the prefrontal white matter tracts of the human brain. This study was cross-sectional and therefore additional longitudinal studies are needed to confirm our findings.

AB - AbstractPrevious diffusion tensor imaging (DTI) studies confirmed the vulnerability of frontal callosal fibers to normal aging. The present study extended this examination systematically to other prefrontal white matter regions. Structural magnetic resonance imaging and DTI datasets were acquired from 69 healthy subjects aged 22–84 years. The prefrontal white matter was parcellated into several anatomical sub-regions: medial and lateral orbitofrontal white matter, dorsolateral prefrontal white matter, and medial prefrontal white matter, using reliable DTI-tractography protocols. Tract-specific characteristics were calculated using Matlab. Regression models were used to determine the relationship between age and structural integrity of white matter tracts. The results of our study demonstrate regional age-related changes in the prefrontal white matter tracts of the human brain. This study was cross-sectional and therefore additional longitudinal studies are needed to confirm our findings.

UR - http://europepmc.org/abstract/med/21559982

U2 - 10.1007/s00429-011-0321-1

DO - 10.1007/s00429-011-0321-1

M3 - Article

C2 - 21559982

SN - 1863-2653

VL - 216

SP - 417

EP - 431

JO - Brain Structure & Function

JF - Brain Structure & Function

IS - 4

ER -

Malykhin N, Vahidy S, Michielse S, Coupland N, Camicioli R, Seres P et al. Structural organization of the prefrontal white matter pathways in the adult and aging brain measured by diffusion tensor imaging. . 2011 Nov;216(4):417-431. doi: 10.1007/s00429-011-0321-1