Selective effects of aging on brain white matter microstructure: a diffusion tensor imaging tractography study. (2024)

Michielse, S., Coupland, N., Camicioli, R., Carter, R., Seres, P., Sabino, J., & Malykhin, N. (2010). Selective effects of aging on brain white matter microstructure: a diffusion tensor imaging tractography study. Neuroimage, 52(4), 1190-1201. https://doi.org/10.1016/j.neuroimage.2010.05.019

Michielse, S ; Coupland, N ; Camicioli, R et al. / Selective effects of aging on brain white matter microstructure: a diffusion tensor imaging tractography study. In: Neuroimage. 2010 ; Vol. 52, No. 4. pp. 1190-1201.

@article{18be66520b324076b814468479ae1b1b,

title = "Selective effects of aging on brain white matter microstructure: a diffusion tensor imaging tractography study.",

abstract = "We examined age-related changes in the cerebral white matter. Structural magnetic resonance images (MRIs) and diffusion tensor images (DTIs) were acquired from 69 healthy subjects aged 22–84 years. Quantitative DTI tractography was performed for nine different white matter tracts to determine tract volume, fractional anisotropy (FA), mean diffusivity (MD), axial, and radial diffusivities. We used automated and manual segmentation to determine volumes of gray matter (GM), white mater (WM), cerebrospinal fluid (CSF), and intracranial space. The results showed significant effects of aging on WM, GM, CSF volumes, and selective effects of aging on structural integrity of different white matter tracts. WM of the prefrontal region was the most vulnerable to aging, while temporal lobe connections, cingulum, and parieto-occipital commissural connections showed relative preservation with age. This study was cross-sectional, and therefore, additional longitudinal studies are needed to confirm our findings.",

author = "S Michielse and N Coupland and R Camicioli and R Carter and P Seres and J Sabino and N Malykhin",

year = "2010",

month = oct,

doi = "10.1016/j.neuroimage.2010.05.019",

language = "English",

volume = "52",

pages = "1190--1201",

journal = "Neuroimage",

issn = "1053-8119",

publisher = "Elsevier",

number = "4",

}

Michielse, S, Coupland, N, Camicioli, R, Carter, R, Seres, P, Sabino, J & Malykhin, N 2010, 'Selective effects of aging on brain white matter microstructure: a diffusion tensor imaging tractography study.', Neuroimage, vol. 52, no. 4, pp. 1190-1201. https://doi.org/10.1016/j.neuroimage.2010.05.019

Selective effects of aging on brain white matter microstructure: a diffusion tensor imaging tractography study. / Michielse, S; Coupland, N; Camicioli, R et al.
In: Neuroimage, Vol. 52, No. 4, 10.2010, p. 1190-1201.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Selective effects of aging on brain white matter microstructure: a diffusion tensor imaging tractography study.

AU - Michielse, S

AU - Coupland, N

AU - Camicioli, R

AU - Carter, R

AU - Seres, P

AU - Sabino, J

AU - Malykhin, N

PY - 2010/10

Y1 - 2010/10

N2 - We examined age-related changes in the cerebral white matter. Structural magnetic resonance images (MRIs) and diffusion tensor images (DTIs) were acquired from 69 healthy subjects aged 22–84 years. Quantitative DTI tractography was performed for nine different white matter tracts to determine tract volume, fractional anisotropy (FA), mean diffusivity (MD), axial, and radial diffusivities. We used automated and manual segmentation to determine volumes of gray matter (GM), white mater (WM), cerebrospinal fluid (CSF), and intracranial space. The results showed significant effects of aging on WM, GM, CSF volumes, and selective effects of aging on structural integrity of different white matter tracts. WM of the prefrontal region was the most vulnerable to aging, while temporal lobe connections, cingulum, and parieto-occipital commissural connections showed relative preservation with age. This study was cross-sectional, and therefore, additional longitudinal studies are needed to confirm our findings.

AB - We examined age-related changes in the cerebral white matter. Structural magnetic resonance images (MRIs) and diffusion tensor images (DTIs) were acquired from 69 healthy subjects aged 22–84 years. Quantitative DTI tractography was performed for nine different white matter tracts to determine tract volume, fractional anisotropy (FA), mean diffusivity (MD), axial, and radial diffusivities. We used automated and manual segmentation to determine volumes of gray matter (GM), white mater (WM), cerebrospinal fluid (CSF), and intracranial space. The results showed significant effects of aging on WM, GM, CSF volumes, and selective effects of aging on structural integrity of different white matter tracts. WM of the prefrontal region was the most vulnerable to aging, while temporal lobe connections, cingulum, and parieto-occipital commissural connections showed relative preservation with age. This study was cross-sectional, and therefore, additional longitudinal studies are needed to confirm our findings.

UR - http://europepmc.org/abstract/med/20483378

U2 - 10.1016/j.neuroimage.2010.05.019

DO - 10.1016/j.neuroimage.2010.05.019

M3 - Article

C2 - 20483378

SN - 1053-8119

VL - 52

SP - 1190

EP - 1201

JO - Neuroimage

JF - Neuroimage

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Michielse S, Coupland N, Camicioli R, Carter R, Seres P, Sabino J et al. Selective effects of aging on brain white matter microstructure: a diffusion tensor imaging tractography study. Neuroimage. 2010 Oct;52(4):1190-1201. doi: 10.1016/j.neuroimage.2010.05.019